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The overall risks for each of the two primary endpoints (the cardiovascular composite and the renal composite) were not reduced with darbepoetin alfa treatment (see Table 1), but the risk of stroke was increased nearly two-fold in the darbepoetin alfa -treated group versus the placebo group: annualized stroke rate 2.1% vs

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In addition to alkyl transfer, several other types of SAM-dependent reactions catalyzed by enzymes have been established including α-deprotonation with the potential for ylide formation (Section 2.5) as well as β-elimination concomitant with elimination of a neutral disulfide (Section 3)